6alpha-Ethyl-chenodeoxycholic acid

6alpha-Ethyl-chenodeoxycholic acid - Names and Identifiers

Name	(3alpha,5beta,6alpha,7alpha)-6-Ethyl-3,7-dihydroxycholan-24-oic acid
Synonyms	6alph 6-Ecdca 6-ECDCA Obeticholic Acid Obeticholic acid 6-ECDCA 6-Ethylchenodeoxycholic aicd 6-Ethylchenodeoxycholic acid Obeticholic Acid(INT 747,6-ECDCA) 6alpha-Ethyl-chenodeoxycholic acid 3A, 7A -DIHYDROXY-6A -ETHYL-5B-CHOLAN-24-OIC ACID (3alpha,5beta,6alpha,7alpha)-6-Ethyl-3,7-dihydroxycholan-24-oic acid
CAS	459789-99-2
EINECS	810-245-2
InChI	InChI=1/C26H44O4/c1-5-17-21-14-16(27)10-12-26(21,4)20-11-13-25(3)18(15(2)6-9-22(28)29)7-8-19(25)23(20)24(17)30/h15-21,23-24,27,30H,5-14H2,1-4H3,(H,28,29)/t15-,16-,17-,18-,19+,20+,21+,23+,24-,25-,26-/m1/s1

6alpha-Ethyl-chenodeoxycholic acid - Physico-chemical Properties

Molecular Formula	C26H44O4
Molar Mass	420.63
Density	1.091
Melting Point	108-110 °C
Boling Point	562.9±25.0 °C(Predicted)
Flash Point	308.3°C
Solubility	DMSO: ≥ 33 mg/mL
Vapor Presure	5.16E-15mmHg at 25°C
Appearance	White solid.
Color	White
pKa	4.76±0.10(Predicted)
Storage Condition	-20°C
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Refractive Index	1.529
Use	This product is for scientific research only and shall not be used for other purposes.
In vitro study	In HuH7 cells, objective Acid is a potent FXR agonist with an EC50 of 85 nM.
In vivo study	In a rat model of cholestasis, objective Acid promotes bile flow and protects hepatocytes from acute necrosis caused by LCA. In WD-fed DBA mice, objective Acid (p.o.) ameliorates proteinuria and renal structural changes, and modulates renal inflammation and oxidative stress. In thioacetamide (TAA)-poisoned and bile duct-ligated (BDL) rats, objective Acid (30 mg/kg p.o.) by reducing the total IHVR, the FXR downstream signaling pathway is restored and portal pressure is reduced without the development of deleterious systemic hypotension.

6alpha-Ethyl-chenodeoxycholic acid - Reference

Reference

1. Zhang, Guoqiang, et al. "Hesperidin alleviates cholestasis via activation of the farnesoid X receptor in vitro and in vivo." European journal of pharmacology 885 (2020): 173498.https://doi.org/10.1016/j.ejphar.2020.173498
2. [IF=4.432] Guoqiang Zhang et al."Hesperidin alleviates cholestasis via activation of the farnesoid X receptor in vitro and in vivo."Eur J Pharmacol. 2020 Oct;885:173498
3. [IF=3.603] Dong Si et al."Functional Amphiphilic Poly(2-oxazoline) Block Copolymers as Drug Carriers: the Relationship between Structure and Drug Loading Capacity."Chinese J Polym Sci. 2021 Jul;39(7):865-873

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View History

6alpha-Ethyl-chenodeoxycholic acid
2-((2-NITROBENZYL)AMINO)ACETIC ACID
C.I. Solvent Orange 53
OTAVA-BB BB7020402297
X-PHOS AMPD SALT
PETROSELINIC ACID(RG)
嘧啶-4-乙酸乙酯
Bz-Phe-Val-Arg-AMC
3-[[(2,6-二氟苯基)磺酰基]氨基]-2-氟苯甲酸甲酯
1-PALMITOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHO-(1'-RAC-GLYCEROL) (SODIUM SALT)

6alpha-Ethyl-chenodeoxycholic acid

(3alpha,5beta,6alpha,7alpha)-6-Ethyl-3,7-dihydroxycholan-24-oic acid

CAS: 459789-99-2

Molecular Formula: C26H44O4

6alpha-Ethyl-chenodeoxycholic acid - Names and Identifiers

6alpha-Ethyl-chenodeoxycholic acid - Physico-chemical Properties

6alpha-Ethyl-chenodeoxycholic acid - Reference

Supplier List

6alpha-Ethyl-chenodeoxycholic acid Request for Quotation

(3alpha,5beta,6alpha,7alpha)-6-Ethyl-3,7-dihydroxycholan-24-oic acid

CAS: 459789-99-2

Molecular Formula: C26H44O4

6alpha-Ethyl-chenodeoxycholic acid - Names and Identifiers

6alpha-Ethyl-chenodeoxycholic acid - Physico-chemical Properties

6alpha-Ethyl-chenodeoxycholic acid - Reference

Supplier List

6alpha-Ethyl-chenodeoxycholic acid